Homotoxicology principles

Homotoxicology is the science of toxins and their removal within the human body, and it is created by the German doctor Hans-Heinrich Reckeweg. According to homotoxicological teachings, a toxin is defined as “A substance that disturbs homeostasis and metabolism” 

Homotoxicology, like Ayurvedic medicine, explains disease evolution in any organ based on 6 main phases, which are divided into 2 types. Phase 1 to 3 is reversible, while phase 4 to 6 is irreversible

The 6 phases of disease evolution in homotoxicology are:

1. Excretion phase (Humoral phase 1): this phase is characterized by hyper-secretions (endocrine) and hyper-excretions. It is rarely symptomatic 

2. Inflammation phase (Humoral phase 2): this phase is characterized by “Acute inflammation”, with the activation of phagocytosis as a first line of defense. Inflammation is a “Cleaning & healing process”, and it should NOT be interrupted by cortisone or anti-inflammatory drugs. In this phase, the parenchymal cells are “Intact” and are NOT affected yet, beside passive injury from free radicals formation due to neutrophils action

3. Deposition phase (Matrix phase 1): this phase arises due to “Failure of the body to get rid of toxins” and toxins start to accumulate in the extracellular matrix causing “Functional dysregulation”. This phase is clinically-silent unfortunately! This phase is seen in many disorders like: “Intestinal polyposis”, “Cysts formation”, “Benign tumors formation”, and “Stones formation

4. Impregnation phase (Matrix phase 2): this phase arises due to “Cellular infiltration” by the toxin or the invading pathogen (e.g., virus). The toxin becomes part of the intracellular components; this will result in enzymes dysfunction, DNA damage, mitochondrial and lysosomal dysfunction, and abnormal protein synthesis. This stage is characterized by “Low-grade, chronic inflammation”, and can be seen in disorders like: viral infections, asthma, migraine, gastric ulcer, angina pectoris … etc.

5. Degeneration phase (Cellular phase 1): this phase arises due to “Cell-to-cell & Cell-to-extracellular matrix communication failure”. The cells and the extracellular matrix are seriously, irreversibly damaged and some of the tissue is replaced by “Fibrosis”. This phase is predominate in “Degenerative disorders” 

6. De-differentiation phase (Cellular phase 2): this phase is characterized by “Abnormal cellular proliferation”. It is predominate in all types of “Malignancies


Selected references

1. Reckeweg HH. Homotoxicology: Illness and healing through anti-homotoxic therapy. 1989; Menaco Publ. Co; 3rd edition


2. International Academy of Homotoxicology


3. Smit A et al. Introduction to Bioregulatory Medicine. 2009; Thieme-Verlag; 1st edition