Enzymes & Coenzymes

Organic chemistry is the chemistry of insulators. For organic and biochemical reactions to occur, a catalyst is needed. In the body, the catalyst is called an “Enzyme”. For this enzyme to function optimally, it needs a helper, a “Coenzyme”. Coenzymes are divided into 2 main groups: Vitamins (called coenzymes) and Minerals (called Cofactors)

As long as our body can make enzymes, we live. Enzyme production decreases with age, illness, and stress situations. Also, enzymes can be depleted by high consumption of: cigarette, caffeine, and all processed & cooked food. Enzymes deficiencies arise mainly as “Chronic GI symptoms” that indicate indigestion such as: bloating, dyspepsia, gallbladder disease, constipation, diarrhea, heartburn …etc.

Enzymes in the body fall into 2 main large groups: digestive & metabolic enzymes. When you eat fresh fruits and vegetables, you ingest their enzymes, which will aid in digestion and reduces the need for “Digestive enzymes production”. The energy reserved from digestive enzymes production will be used in “Metabolic enzymes production”, which will cause the body to thrive

When the food ingested is devoid of any digestive enzymes, the body has to put all his resources in making enough digestive enzymes to digest the food, which in normal situations is NOT enough; this will deplete the body’s ability to make metabolic enzymes, causing chronic body disease 

Enzymes are specific for one pathway. For example, a metabolic pathway with 12 consecutive reactions will require 12 different enzymes to finish. This also means that the whole pathway can be blocked if any one of the enzymes is not there or somehow is switched off. In the cells, the enzymes will not work properly if the temperature (e.g., 37oC) or the pH (e.g., 7.34) is not optimal

Some enzymes are present in the plasma in two or more molecular forms. These variants are known as “Isoenzymes” and, although they have different structures, they perform the same catalytic function. Different isoenzymes may arise from different tissues and their specific detection may give clues to the site of pathology. Alkaline phosphatase isoenzymes, for example, may distinguish between bone and liver disease, especially in patients in whom metastases of bone or liver are suspected

Enzymes depletion disorders

(Cancer as an example)

Normal body cells are “Alkaline” and “Negatively-charged”, while cancerous cells are “Acidic” and “Positively-charged”. Cancer cells form a protein coat around them that is “Negatively-charged” masking them from natural killer cells, which are also negatively-charged (they repel each other). Pancreatic enzymes (e.g., pancreatine, chromotrypsin) in the blood digest the cancerous protein coat, exposing them to the natural killers and the immune system

Pancreatin, an enzyme secreted by the pancreases to digest proteins, digests the malignant tumor masses and cells into liquid debris. This debris is then gobbled up by your white blood cells and removed from your body by way of bile from the liver, which goes into the colon and out, and urine from the kidneys, which goes into the bladder and out

Up to 86% of cancers can be controlled by diet and pancreatic enzymes. In reality, cancer can be considered as a disorder of “Protein metabolism disturbance”, where the body is deficient in protein digestive enzymes (Like diabetes considered as a disorder of “carbohydrates metabolism disturbance). The body fails to produce protein digestive enzymes due to:

A. Overworked pancreas due to intake of too much proteins (83%). The body uses its resources to produce pancreatic enzymes and other metabolic enzymes. When you consume a lot of meat, you exhaust the body by creating too many pancreatic enzymes and reducing the body resources to produce other enzymes, especially those important for the immune system

B. Neurological injury to the pancreas (10%)

C. Abnormal body chemistry inactivating the enzymes (7%)

Notice: both insulin (Diabetes) and pancreatic enzymes (Cancer) are traced to pancreas disorder!!!! 


Selected references

1. Cichoke AJ. The Complete Book of Enzyme Therapy: A Complete and Up-to-Date Reference to Effective Remedies. 1998; Avery Trade; 1 edition


2. Cichoke AJ et al. Enzymes & Enzyme Therapy: How to Jump-Start Your Way to Lifelong Good Health. 2000; McGraw-Hill Education; 2nd edition